This is a list of notable events, premieres, releases, series cancellations and endings, and other business ventures for Nickelodeon in the year 1999.
- Noggin debuts as its own channel.
- Nick GaS debuts as its own channel.
- Henry & June's Nicktoons Summer Jam replaces Nick in the Afternoon as the annual summer weekday afternoon block.
- January 17 - The Brothers Flub, an animated series by SunBrow Animation, starts its run on Sunday mornings.
- February 8 - Kipper premieres on Nick Jr., before it was moved to Noggin in 2001.
- February 11 - Maisy premieres on Nick Jr., before it was moved to Noggin in 2001.
- May 1 - SpongeBob SquarePants premieres after the Kids' Choice Awards; it would begin regularly airing on July 17th.
- August 16 - Rocket Power premieres in primetime.
- October 16 - 100 Deeds for Eddie McDowd and The Amanda Show debut on an revamped SNICK, entitled SNICK House.
- November 28 - Little Bill premieres in primetime.
- December 31 - ChalkZone premieres its first episode as part of the Nick New Year's block, but the rest of the first season would be delayed to 2002.
- February 6 - The revival of Are You Afraid of the Dark? premieres.
- November 27 - Season 6, what originally was the final season for All That, begins its run.
- The Off-Beats' Valentines
- The Henry & June Show
- February 20 - Nick GaS ends its run, in preparation for its channel's launch.
- March 27 - Nicktoons TV airs its final broadcast; it would become its own channel in 2002.
- June - Henry & June's Nicktoons Summer Jam debuts, and would continue for the rest of the summer.
- July 7 - Nick Flicks movie block begins.
- September - 101% Whizbang! With Henry and June debuts on weekday afternoons.
- November - U-Pick Fridays
- February 28 - The Rugrats Movie (Game Boy Color)
- June 29 - Rugrats: Scavenger Hunt
- November 10 - Rugrats: Studio Tour
- March 1 - Aliens
- May 1 - Summer Vacation
- June 1
- Tommy's Last Stand
- July 1 - Cat's Big Night / Dog Behind Bars
- August - CatDog's Big Idea
- September 1
- October 1
- November 1
Home video releases
- March 30
- CatDog: Together Forever
- CatDog: CatDog vs. the Greasers
- The Rugrats Movie
- August 3 - Rugrats: Runaway Reptar
- October 1 - Rugrats: Make Room for Dil
- March 30 - Nickelodeon enters the DVD market with Paramount Home Video's DVD release of The Rugrats Movie
- February 10 - Tiffany Espensen is born
- March 21 - Lexi DiBenedetto is born
- May 5 - Jonny Gray is born
- May 25 - Brec Bassinger is born
- September 7 - Cameron Ocasio is born
- September 13 - Zoey Burger is born and resign
- October 15 - Bailee Madison is born
- November 1 - Buddy Handleson is born
- November 11 - Mary Kay Bergman (the original voice of Timmy Turner) dies
Nickelodeon character debuts
- Oh Yeah! Cartoons: Penny Sanchez, Tootie, Jorgen Von Strangle
- SpongeBob SquarePants: SpongeBob SquarePants, Patrick Star, Squidward Tentacles, Mr. Krabs, Sheldon Plankton, Karen Plankton, Sandy Cheeks, Mrs. Puff, Pearl Krabs, Gary the Snail, Mermaid Man and Barnacle Boy, Bubble Bass
- Rocket Power: Otto Rocket, Sam Dullard, Twister Rodriguez, Reggie Rocket, Tito Makani, Raymundo Rocket
- The Amanda Show: Penelope Taynt, Crazy Courtney