This is a list of notable events, premieres, releases, series cancellations, endings and other business ventures for Nickelodeon in the year 2000.
- Original shows
- January 22 - Double Dare 2000
- March 11 - Caitlin's Way
- June 5 - Maggie and the Ferocious Beast
- July 23 - The Brothers Garcia
- August 14 - Dora the Explorer
- October 7 - Noah Knows Best
- October 24 - Pelswick
- October 25 - As Told by Ginger
- January 15 - KaBlam!
- April 23 - The Journey of Allen Strange
- July 15 - Kenan & Kel, All That
- August 25 - Mr. Wizard's World
- November 10 - Double Dare 2000
- January 1 - Nickmillenium (worldwide and Noggin) All Day
- Network debuts
- January 24 - The Beverly Hillbillies
- March 28 - Ghostwriter
- March 29 - Cro
- April 30 - A Walk in Your Shoes
- June 4 - Gilligan's Island
- June 5 - Shining Time Station
- July 3 - The Andy Griffith Show
- July 7 - Head of the Class
- July 14 - Perfect Strangers
- September 4
- Bill Nye, the Science Guy
- Pinky and the Brain
- The Facts of Life
- 3-2-1 Contact
- October 15 - Three's Company
- Network departures
- Garfield and Friends
- January - Slime Time Live premieres.
- January 12 - Nick Flicks ends.
- June 28 - The SpongeBob's Nicktoon Summer Splash summer block premieres.
- The Nickel-o-Zone ends.
- July 22 - Kenan & Kel: Two Heads Are Better Than None
- October 28 - Cry Baby Lane
- November 25 - CatDog: The Great Parent Mystery
- November 12 - Rugrats in Paris: The Game
- Chuckie Meets the Beastie Bunny
- Open Wide: A Visit to the Dentist
- A Tale of Two CatDogs
- May - Rugrats Discover America (book)
- July 1 - It Takes Two!
- September 1
- January 11
- Blue's Clues: Blue's Safari
- Little Bear: A Kiss for Little Bear
- Rugrats: I Think I Like You
- March 7
- Blue's Clues: Magenta Comes Over
- Blue's Clues: Big, Blue and Just for You!, Volume 4
- Little Bear: Little Bear's Band
- May 5
- Rugrats: Discover America
- Rugrats: Volume 6
- June 6
- Blue's Clues: Stop, Look and Listen!
- Little Bear: Rainy Day Tales
- October 3
- Blue's Clues: Blue's Big Musical Movie
- Snow Day
- The Wild Thornberrys: A Thornberry Christmas (Toys 'R' Us exclusive)
- February 1 - Paris Smith is born
- February 25
- March 6 - Jacob Bertrand is born
- March 21 - Jace Norman is born
- April 21 - Rolante Yomti is born
- June 2 - Lilimar is born
- June 13 - Daniella Perkins is born
- July 19 - Owen Joyner is born
- August 20 - Fatima Ptacek is born
- October 31 - Willow Smith is born
- November 8 - Jade Pettyjohn is born
- Nick 2 is launched.
Nickelodeon character debuts
- Rugrats: Lulu Pickles
- Dora the Explorer: Dora, Boots, Swiper, Backpack, Map, Benny, Tico, Isa, Grumpy Old Troll, Elena and Cole Márquez, Valerie Márquez, Wizzle, Señor Tucán, Azul, Pirate Piggies, Pirate Parrot, Baby Red Fish, Val The Octopus, Big Red Chicken, Baby Blue Bird
- Blue's Clues: Periwinkle
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