This is a list of notable events, premieres, releases, series cancellations and endings, and other business ventures for Nickelodeon in the year 2006.
- February 25 - Kappa Mikey
- March 3 - Wonder Pets
- August 28 - Wow! Wow! Wubbzy!
- September 22 - Mr. Meaty
- October 16 - The Upside Down Show premiered on Nick Jr.
- August 6 - Blue's Clues, six seasons
- August 19 - Invader Zim, two seasons (cancelled on January 17, 2002, although the final unaired episode aired on Nicktoons Network on this date)
- November 14 - As Told By Ginger, three seasons
- November 25 - The Adventures of Jimmy Neutron: Boy Genius, three seasons
- December 13 - The X's, one season
- March 3, 2006 - Avatar: The Last Airbender season two
- September 24, 2006 - Drake & Josh season four
- September 24, 2006 - Zoey 101 season three
- October 6, 2006 - Danny Phantom season three
- January 16 - Jimmy Timmy Power Hour 2: When Nerds Collide!
- May 19 - Fairy Idol
- July 21 - Jimmy Timmy Power Hour 3: The Jerkinators!
- July - Hi-5: Series 7 premiered on Nick Jr. in Australia.
- October 16 - The Upside Down Show premiered on Nick Jr. in October 16, 2006 in Australia.
- January 6 - Drake & Josh Go Hollywood
- Nicktoons Unite! (Nintendo DS)
- October 18 - The Fairly OddParents: Clash with the Anti-World
- October 24 - Nicktoons: Battle for Volcano Island
- November 13 - SpongeBob SquarePants: Creature from the Krusty Krab
- August 8 - Blue's Clues: Blue's Biggest Hits
- September 12 - SpongeBob SquarePants: The Best Day Ever
Home video releases
- January 31 - Drake & Josh Go Hollywood
- February 7 - Nick Picks: Volume 3
- February 21 - SpongeBob SquarePants: Lost in Time
- March 14 - Jimmy Timmy Power Hour 2
- April 18 - Are You Afraid of the Dark?: Season 1 & TEENick Picks Volume 1
- May 23 - The Fairly OddParents: Fairy Idol
- June 6 - Nick Picks: Volume 4
- July 18 - SpongeBob SquarePants: Karate Island
- July 25 - Jimmy Timmy Power Hour 3
- September 5 - Rugrats: Tales from the Crib: Three Jacks & The Beanstalk
- September 12 - SpongeBob SquarePants: Season 4, Volume 1
- September 26
- Nick Jr. Favorites: Holiday
- Nick Picks: Holiday
- October 3 - Are You Afraid of the Dark?: Freaky Favorites
- October 10
- Dora The Explorer: World Adventure
- The Backyardigans: Mission To Mars
- October 17 - Nick Picks: Volumes 1-3 (box set)
- October 18 - Nick Jr. Favorites: Volume 2
- October 31 - SpongeBob SquarePants: Whale of a Birthday
- November 28 - Are You Afraid of the Dark?: Season 2
- December 12 - Barnyard
- January 25 - SpongeBob SquarePants: Season One
- February 28 - SpongeBob SquarePants: Season Two
- May 29 - The Fairly OddParents: Seasons One and Two
- June 12 - Danny Phantom: Season One
- October 16 - The Fairly OddParents: Season Three
- November 5 - SpongeBob SquarePants: Season Three
- November 6 - SpongeBob SquarePants: Season Four
March 7 - Zoey 101: Music Mix April 11 - Diego, Dora, and Friends Animal Jamboree
- January 3 - A new Viacom begins operations, after being spun off from CBS Corporation, formerly known as Viacom. This new Viacom retains control over Nickelodeon and its sister networks.
- January 6 - Lou Rawls (voice actor on Hey Arnold!) dies
- July 21 - Mako Iwamatsu (voice actor on Avatar: The Last Airbender) dies