Alisa Jasmine Carmichael is the oldest child in the Carmichael family on Rugrats. Alisa and the rest of her family made their first appearance in Meet the Carmichaels. Alyssa is a typical teenager: desires more independence, loves gossiping on the phone, enjoys hanging out with her friends and boyfriend, Tad, and is also overly concerned about her appearance (she once overreacted when her younger sister, Susie, unintentionally pointed out a zit to her).
In the original series, Alyssa is 16 years old, thirteen years older than Susie, so she's old enough to drive a car. Like Angelica Pickles' mom, Charlotte, Alisa spends much of her free time talking on the phone. Alisa feels that her parents (mainly her father) treat her like a little kid instead of having to treat her like a teenager, and wants to be more independent, but despite that, Alisa enjoys spending time with her younger siblings (especially Susie), and even enjoys reading children's books to her sister and Tommy Pickles.
Alisa's most prominent role was in the episode "The Last Babysitter", in which she is given a chance to prove to her parents (mainly her father) that she's responsible by babysitting her siblings and Tommy while their parents go to a concert. However, the lights go off and she gets nervous as she hears some noise downstairs. Her younger brother, Buster, volunteers to go and see for her, then rushes up saying there was "something" downstairs. Alisa insists on calling their parents, but the phone's dead. Susie, wanting to help her older sister with her baby-sitting job, gets Tommy to sneak upstairs with her and look for the "monster". As they do, Alisa realizes they're gone and begins to worry when she can't find them downstairs, oblivious that Buster's enjoying seeing her freak out. Eventually, Susie and Tommy find the "monster's" hair and come back downstairs, showing it to her. But Alisa begins to piece everything together when she realizes that they had found Buster's old wig for his Halloween costume the previous year. As they go to investigate Buster's room, she realizes that he and his friend, Sticky, were pulling a prank on her for sending the latter home. To that, Alisa stands her ground, making them fix the lights, sending Sticky home and sending Buster to bed early for the prank. Afterwards, Alyssa thanks Susie and Tommy for being there for her.
Alisa also appears as an adult in the spin-off series, All Grown Up!, in its first episode, "Susie Sings The Blues". After Susie is falsely told she has to come up with $1000 to fund an audition, Kimi reveals that Alisa and her boyfriend were saving to buy a house, so Susie goes to ask her for the money. After some convincing, she reluctantly agrees to loan Susie the money, only for Susie to be tricked by the con artist named Beverly Jones. In the end, while Alisa is obviously very mad at her sister, she's glad that Susie's okay and calmly allows to pay her back. Later, in the fourth-season episode "In the Family's Way", it is revealed that Alisa has married a man named Ty and has a daughter named Gabrielle.
- On the Cooltoons2 website (which is managed by Klasky Csupo), her name is misspelled as "Alyssa" on her All Grown Up! bio.
- Despite being a sibling of one of the main characters, Alisa does not appear to be present in the 2021 Rugrats reboot.