The show revolves around Blue'a adventures in her new playroom, where she transforms from a barking cartoon character into a talking puppet dog. There, she has fun with her playroom friends; Roary Sarus, Fred, Polka Dots (her doll from the original series) and Moona the Moon Fairy and shows the viewers how to have a good time in creative ways. Sometimes, Joe stops by for a visit to join in on the fun. Also introducing the newest member of Blue's family is her new little brother, Sprinkles.
Besides Blue and Joe, none of the other Blues Clues characters appeared. However, Mailbox, Slippery, Mr. Salt, Mrs. Pepper, Paprika, Cinnamon and Tickety did appear in the special "Meet Blue's Baby Brother'.
Polka Dots is Blue's best friend, a sea-green plush toy who creates puzzles for others to solve. He often acts as a co-host to the show. Puppeteered by Peter Linz.
Frederica (also known as Fred) is one of Blue's other best friends that usually pretends it is her birthday everyday. Puppeteered by Cheryl Blaylock.
Roar E. Saurus (also known as Roary) is a dinosaur who likes to practice roaring. Puppeteered by Joey Mazzarino.
Joe is a human and Blue's caretaker. He is often seen alongside Sprinkles. Portrayed by Donovan Patton.
Sprinkles is Blue's baby brother. He is a somewhat shy spotted puppy. Puppeteered by Joey Mazzarino.
List of episodes
Season 1 (2004-2005)
- Snacktime Playdate (August 2, 2004)
- Fred's Birthday (November 24, 2004)
- Blue's Holiday Wishes (December 3, 2004)
- It's Hug Day! (January 7, 2005)
- Beyond Your Wildest Dreams! (April 18, 2005)
- The Power of the Alphabet (September 17, 2005)
- Meet Blue's Baby Brother (August 6, 2006)
Season 2 (2006-2007)
- Blue's Farm Playdate (January 26, 2007)
- Shape Detectives (February 2, 2007)
- Masterpiece Museum (February 9, 2007)
- World Travelers (February 16, 2007)
- Away Great Playdate (February 16, 2007)
- Sprinkles' Sleepover (March 26, 2007)
- Little Red Riding Blue (March 26, 2007)
- Music Stars (March 26, 2007)
- Knights of the Snack Table (March 27, 2007)
- Mathstronauts! (March 29, 2007)