Glowface is The X's arch-enemy, leader of S.N.A.F.U, and the main antagonist of the series. Glowface's head is encased in a glass globe with electrical discharges. He wears a rubber suit and gloves to contain his vast energies. His schemes to get rid of the X's include having Mrs. X break her leg on a coffee table and sending them coupons for family portraits. Like traditional evil villains, Glowface is megalomaniacal, arrogant, loudmouthed and delusional, but he possesses little sophistication or maturity, and believes himself to be much more of a threat than he actually is. Similar to Austin Powers' arch-enemy Dr. Evil, Inspector Gadget's arch-enemy Doctor Claw, James Bond's arch-enemy Ernest Blofield, he also tends to think up idiotic evil schemes like building a giant ray gun in order to bring the Eiffel Tower and Big Ben to life in order for them to wrestle so he can sell tickets. He has very poor teeth and once had to get braces. Glowface is disdainful of his nephew Brandon's crush on Tuesday. Glowface is also allergic to Zucchini and has an unseen way of eating food. The only thing that Glowface and Mr. X have in common are building model train sets. He was voiced by Chris Hardwick.

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