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This is a list page for episodes from the fourth season of Go, Diego, Go!, listed in production order.
This season premiered the day of the rebrand on Nickelodeon and Nick Jr, as well as Nicktoons Network becoming NickToons, The N becoming TeenNick, and Noggin becoming the Nick Jr. Channel.
All episodes premiered on Nickelodeon and the Nick Jr. Channel.
Episodes[]
| # | Title | Airdate |
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| 57 | Diego Reunites Hippo and Oxpecker | September 28, 2009  
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| 58 | Diego's Orangutan Rescue | September 29, 2009
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| 59 | Where is Okapi's Brother? | September 30, 2009
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| 60 | Puffin Fish Adventure | October 1, 2009
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| 61 | All Aboard the Giant Panda Express! | February 19, 2010
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| 62 | Diego's Ringed Seal Rescue | March 15, 2010
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| 63 | Bengal Tiger Makes a Wish! | March 16, 2010
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| 64 | Leaping Lemurs | March 17, 2010
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| 65 | Diego Saves the Beavers | March 18, 2010
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| 66 | Ocean Animal Rescuer | April 22, 2010
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| 67 | Welcome Home, Lion Cub! | June 18, 2010
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| 68 | Diego's International Rescue League | September 24, 2010
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