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Mary Patrick Gleason (born February 23, 1950 - died June 2, 2020) was an American film and television actress and an Emmy Award winning writer. From 1983 to 1985, she appeared on Guiding Light as Jane Hogan.

Her first screen role was the a 1982 episode of Texas, a soap opera that aired on NBC. She also appeared on such television series as Full House, Dear John, Murphy Brown, Empty Nest, L.A. Law, Saved by the Bell, Murder, She Wrote, Friends, Step by Step, Suddenly Susan, Will & Grace, Sex and the City, Desperate Housewives, Family Matters, NCIS: Los Angeles, The Middleman, Up All Night, 1600 Penn, Motive, Baby Daddy, Grey's Anatomy, Partners, Mama's Family, The Blacklist, wikipedia:American Housewife American Housewife, 2 Broke Girls and wikipedia:Mom (TV series) Mom.

She also appeared in such feature films as I Now Pronounce You Chuck & Larry, Basic Instinct, Traffic, Bruce Almighty, 13 Going on 30, The Crucible, Bottle Shock, A Cinderella Story, The Island, Killing Kennedy and Nina.

She also starred as Professor Foxtrot in the web show WTF 101 on CollegeHumor's Dropout platform.

On Nickelodeon, she played the role of Mrs. Gosnold from the series Instant Mom and voiced Earth Mama from the television film Albert.

On June 2, 2020, Gleason died from cancer at age 70.