The show revolves around the antics of Romeo Miller, an aspiring rapper, his musically mediocre family, and his record-producing father, Master P. Romeo is part of a hip-hop band, along with his siblings Louis, Gary, and Jodi, and the show primarily follows the adventures that the family, along with Romeo's nanny and stepmother, get involved in.
- Romeo Miller as Romeo "Ro" Miller
- Master P as Percy Miller
- Erica O'Keith as Jodi Miller
- Noel Callahan as Louis Testaverde
- Zachary Isiah Williams as Gary Miller
- Victoria Jackson as Marie Rogers (season 1)
- Natashia Williams as Angie Miller (seasons 2-3)